Physiology

Download E-books Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology PDF

By P. Rustin, G. Kroemer (auth.), G. Kroemer, D. Mumberg, H. Keun, B. Riefke, T. Steger-Hartmann, K. Petersen (eds.)

In Nineteen Twenties, Otto Warburg defined the phenomenon of ‘aerobic glycolysis’, the power of tumour cells to transform glucose to lactate within the presence of standard oxygen stipulations. Warburg’s speculation of an altered metabolism in melanoma cells stumbled on no quick attractiveness, notwithstanding it used to be latter proven for many human tumours. With the arrival of molecular biology the point of interest in tumour examine has shifted in the direction of the quest for oncogenes. despite the fact that, the curiosity in melanoma molecular profiling ultimately ended in a renaissance of the Warburg impression attempting to mix genetic changes with results on metabolism with assistance from glossy analytic applied sciences to speedily learn large sorts of metabolites in quite a few tissues and bodyfluids (metabonomics).

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