Designed as a first-stop reference for researchers and execs in toxicology, pharmacology and drugs, this instruction manual is the first actual to tie jointly the data from many disciplines that has to this point been to be had merely from largely dispersed assets within the basic literature. As such, it provides the total photo on what's at the moment identified approximately endogenous pollution, together with their iteration, mode of motion, ensuing affliction , and to be had countermeasures.
sincerely divided into 4 elements, the 1st systematically covers vital poisonous molecule species, together with metabolic intermediates and reactive oxygen species. the second one discusses the position of genetically decided metabolic malfunctions, equivalent to galactosemia, hyperlipidemia, porphyria, hemochromatosis and similar stipulations, whereas half 3 appears to be like at received and protracted ailments triggered or exacerbated by means of endogenous pollution, akin to hepatic damage, bronchial asthma, rheumatism, colorectal melanoma, reperfusion ailments, neurodegneration and getting older. the ultimate half studies currents thoughts to regulate and reduce the influence of endogenous pollution, both through dietary or pharmacological interventions.
With its whole insurance integrating molecular and systemic features from the biochemical foundation to human illness stipulations, this finished reference will attract a huge goal team of toxicologists, biochemists, foodstuff experts and physicians.
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