Download E-books Cell Calcium Metabolism: Physiology, Biochemistry, Pharmacology, and Clinical Implications PDF

By Sophie Lotersztajn, Catherine Pavoine, Ariane Mallat, Dominique Stengel, Paul Insel (auth.), Gary Fiskum (eds.)

A common appreciation for the function that calcium performs in phone body structure and patho­ body structure has now been accomplished as a result of the pioneering reviews of the various scientists who attended the VIIth overseas Spring Symposium on healthiness Sciences at George Washington college in Washington, D. C. The members during this specific assembly rep­ resented assorted fields of uncomplicated and medical examine, corresponding to molecular body structure, oncology, molecular genetics, cardiology, bioenergetics, pathology, and endocrinology. The content material of the court cases of the symposium represents paintings in those and different components of biomedical study. association of the publication is aimed toward outstanding a stability among the biochemistry 2 and body structure of ordinary telephone Ca + metabolism and the pathological outcomes of al­ 2 terations in mobilephone Ca + homeostasis. the 1st part of the booklet is dedicated to the shipping mechanisms answerable for 2 2 regulating intracellular Ca + and the pharmacological modalities for controlling mobile Ca + . specific realization is given to the molecular foundation for plasma membrane shipping actions, 2 2 together with the ATP-driven Ca + pump, the Na + -Ca + trade procedure, and voltage delicate 2 Ca + channels. the second one part covers the interesting relationships among phosphoinositide metab­ 2 olism, sign transduction, and mobile Ca + metabolism. This part starts off with an eloquent evaluation via Professor Michael Berridge, who was once the keynote speaker on the symposium and the recipient of the clinical advantage award.

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