Download E-books Cardiac Gap Junctions: Physiology, Regulation, Pathophysiology and Pharmacology PDF

By S. Dhein

An important conversation mechanism among cardiac cells is electric transmission through low resistance pathways, the so-called hole junction channels. This e-book offers a complete evaluate of what's recognized approximately cardiac hole junctions. An advent into many of the features of activation propagation and coupling within the center is by way of a close description of the constitution and variety of hole junctions, together with amino acid sequences and species variability. next chapters speak about their distribution, body structure and capabilities and the rules of expression. the writer then is going directly to positioned those simple findings right into a scientific context - the adjustments of hole junction distribution during cardiac affliction and their implications. an extra bankruptcy offers pharmacological methods to the modulation of hole junction channel conductivity and descriptions attainable healing concepts. the ultimate a part of the e-book describes the equipment of research together with double mobilephone voltage clamp, immunohistochemistry, isolation techniques for hole junctions and dye coupling assays.

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